UniProt ID: F1R4S7 |
FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000256|HAMAP-Rule:MF_03169}. CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence={ECO:0000256|HAMAP-Rule:MF_03169}; SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_03169}. SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|HAMAP-Rule:MF_03169}. DOMAIN: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis. {ECO:0000256|HAMAP-Rule:MF_03169}. SIMILARITY: Belongs to the adenylate kinase family. AK3 subfamily. {ECO:0000256|HAMAP-Rule:MF_03169}. |
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