UniProt ID: A0A8M9PTS3 |
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|RuleBase:RU364148}. SUBUNIT: Component of the Mediator complex. {ECO:0000256|RuleBase:RU364148}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364148}. SIMILARITY: Belongs to the Mediator complex subunit 15 family. {ECO:0000256|ARBA:ARBA00009807, ECO:0000256|RuleBase:RU364148}. |
UniProt ID: A0A8M9PI73 |
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|RuleBase:RU364148}. SUBUNIT: Component of the Mediator complex. {ECO:0000256|RuleBase:RU364148}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364148}. SIMILARITY: Belongs to the Mediator complex subunit 15 family. {ECO:0000256|ARBA:ARBA00009807, ECO:0000256|RuleBase:RU364148}. |
UniProt ID: Q7ZVN7 |
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol- dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway. {ECO:0000250, ECO:0000269|PubMed:17208216}. SUBUNIT: Component of the Mediator complex. Interacts with srebf1 and srebf2. Interacts with smad2, smad3 and smad4 (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. SIMILARITY: Belongs to the Mediator complex subunit 15 family. {ECO:0000305}. |
UniProt ID: F1QFA9 |
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|RuleBase:RU364148}. SUBUNIT: Component of the Mediator complex. {ECO:0000256|RuleBase:RU364148}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364148}. SIMILARITY: Belongs to the Mediator complex subunit 15 family. {ECO:0000256|ARBA:ARBA00009807, ECO:0000256|RuleBase:RU364148}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |