UniProt ID: Q6PBM1 |
FUNCTION: Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:16110529). Receives iron-sulfur clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:16110529). Required for normal hemoglobin biosynthesis (PubMed:16110529). {ECO:0000269|PubMed:16110529}. SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q86SX6}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16110529}. DEVELOPMENTAL STAGE: Detected in embryonic intermediate cell mass (site of hematopoiesis), liver and heart. DISRUPTION PHENOTYPE: Lethal between 7 and 10 dpf. Embryos show hypochromia, and circulating blood cells are pale due to a defect in hemoglobin biosynthesis. {ECO:0000269|PubMed:16110529}. |
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