UniProt ID: Q6NWJ4 |
FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity). {ECO:0000250|UniProtKB:Q99543}. SUBUNIT: Component of ribosome-associated complex (RAC). {ECO:0000250|UniProtKB:Q99543}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99543}. SEQUENCE CAUTION: Sequence=AAH55125.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; |
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