UniProt ID: Q6P6E6 |
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. {ECO:0000250|UniProtKB:Q8WXC6}. SUBUNIT: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9. {ECO:0000250|UniProtKB:Q8WXC6}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXC6}. Cytoplasm {ECO:0000250|UniProtKB:Q8WXC6}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8WXC6}. SIMILARITY: Belongs to the CSN9 family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH62283.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
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