UniProt ID: Q6PBW5 |
FUNCTION: Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). {ECO:0000250|UniProtKB:Q16518, ECO:0000305|PubMed:17868371}. CATALYTIC ACTIVITY: Reaction=an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+); Xref=Rhea:RHEA:31771, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16302, ChEBI:CHEBI:28868, ChEBI:CHEBI:63410; EC=3.1.1.64; Evidence={ECO:0000250|UniProtKB:Q28175}; CATALYTIC ACTIVITY: Reaction=lutein = (3R,3'S)-zeaxanthin; Xref=Rhea:RHEA:12729, ChEBI:CHEBI:28838, ChEBI:CHEBI:138919; EC=5.3.3.22; Evidence={ECO:0000250|UniProtKB:Q16518}; CATALYTIC ACTIVITY: Reaction=all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate; Xref=Rhea:RHEA:31775, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16302, ChEBI:CHEBI:17616; EC=3.1.1.64; Evidence={ECO:0000250|UniProtKB:Q16518}; COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250|UniProtKB:A9C3R9}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250|UniProtKB:A9C3R9}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A9C3R9}. Cell membrane {ECO:0000250|UniProtKB:A9C3R9}; Lipid-anchor {ECO:0000250|UniProtKB:A9C3R9}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. {ECO:0000250|UniProtKB:Q28175}. TISSUE SPECIFICITY: Retinal pigment epithelium-specific. {ECO:0000269|PubMed:17868371}. DEVELOPMENTAL STAGE: Expressed at 16 hours post fertilization (hpf) in the pineal gland, a light-sensitive endocrine organ. Expression in the retinal pigment epithelium (RPE) is initiated in the ventronasal patch at 40 hpf, preceding photoreceptor differentiation by a few hours. During subsequent development, expression in the RPE becomes stronger and more widespread, covering the entire RPE except for the cilliary margin by 56 hpf. {ECO:0000269|PubMed:17868371}. PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q28175}. SIMILARITY: Belongs to the carotenoid oxygenase family. {ECO:0000305}. |
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