UniProt ID: Q7SXJ6 |
FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). May also acts as a positive regulator of the Wnt signaling (PubMed:27007149). {ECO:0000250|UniProtKB:Q96BH1, ECO:0000269|PubMed:27007149}. CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q96BH1}; PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96BH1}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27007149}. SIMILARITY: Belongs to the RNF25 family. {ECO:0000305}. |
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