UniProt ID: Q7SXP2 |
FUNCTION: Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). The covalent attachment of nedd8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. {ECO:0000250|UniProtKB:Q13564}. PATHWAY: Protein modification; protein neddylation. SUBUNIT: Heterodimer of uba3 and nae1. The complex binds nedd8 and ube2m (By similarity). {ECO:0000250}. SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH50171.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
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