UniProt ID: Q6TH47 |
FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity). {ECO:0000250|UniProtKB:O95630}. COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:O35864}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250|UniProtKB:O35864}; DOMAIN: The JAMM motif is essential for the protease activity. {ECO:0000250|UniProtKB:O35864}. SIMILARITY: Belongs to the peptidase M67C family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |