UniProt ID: Q6PFQ5 |
FUNCTION: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. {ECO:0000256|HAMAP- Rule:MF_03211}. CATALYTIC ACTIVITY: Reaction=a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:51424, Rhea:RHEA-COMP:13575, Rhea:RHEA-COMP:13576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence={ECO:0000256|HAMAP-Rule:MF_03211}; CATALYTIC ACTIVITY: Reaction=a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)- acetylcytidine in tRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:53876, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:13671, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence={ECO:0000256|HAMAP-Rule:MF_03211}; SUBUNIT: Interacts with THUMPD1. {ECO:0000256|HAMAP-Rule:MF_03211}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|HAMAP-Rule:MF_03211}. SIMILARITY: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily. {ECO:0000256|HAMAP-Rule:MF_03211}. |
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