UniProt ID: Q6NWF1 |
FUNCTION: Insulin-regulated facilitative glucose transporter. {ECO:0000269|PubMed:25326603}. CATALYTIC ACTIVITY: Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence={ECO:0000305|PubMed:25326603}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BFW9}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q5J316}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TD20}. Note=Localizes primarily perinuclear region in the absence of insulin. {ECO:0000250|UniProtKB:Q8TD20}. TISSUE SPECIFICITY: Expressed in the main insulin-sensitive tissues, such as cardiac muscle, skeletal muscle and adipose tissue. {ECO:0000269|PubMed:25326603}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein impairs the development of the embryonic heart resulting in abnormal valve formation (PubMed:25326603). Embryos also show poor glycemic control (PubMed:25326603). {ECO:0000269|PubMed:25326603}. SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO:0000305}. |
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