UniProt ID: Q7T326 |
FUNCTION: Regulator of autophagy that contributes to antagonize becn1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity). {ECO:0000250}. COFACTOR: Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250}; SUBUNIT: Homodimer. {ECO:0000250}. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=CAX13850.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
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