UniProt ID: Q7T330
FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity). {ECO:0000250}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
DOMAIN: The BTB (POZ) domain mediates dimerization and interaction with CUL3. {ECO:0000250}.
DOMAIN: The MATH domain mediates interaction with protein- ubiquitin ligase substrates. {ECO:0000250}.
SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}.
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