UniProt ID: Q7T330 |
FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. DOMAIN: The BTB (POZ) domain mediates dimerization and interaction with CUL3. {ECO:0000250}. DOMAIN: The MATH domain mediates interaction with protein-ubiquitin ligase substrates. {ECO:0000250}. SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}. |
UniProt ID: A7YYH8 |
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}. SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}. SIMILARITY: Belongs to the Tdpoz family. {ECO:0000256|ARBA:ARBA00010846}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |