UniProt ID: Q7T384 |
FUNCTION: Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. {ECO:0000269|PubMed:17255103}. CATALYTIC ACTIVITY: Reaction=(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in); Xref=Rhea:RHEA:75791, ChEBI:CHEBI:16651, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=Na(+)(out) + nicotinate(out) = Na(+)(in) + nicotinate(in); Xref=Rhea:RHEA:75795, ChEBI:CHEBI:29101, ChEBI:CHEBI:32544; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=Na(+)(out) + pyruvate(out) = Na(+)(in) + pyruvate(in); Xref=Rhea:RHEA:75799, ChEBI:CHEBI:15361, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in); Xref=Rhea:RHEA:75807, ChEBI:CHEBI:17272, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in); Xref=Rhea:RHEA:75803, ChEBI:CHEBI:17968, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; CATALYTIC ACTIVITY: Reaction=acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in); Xref=Rhea:RHEA:75811, ChEBI:CHEBI:13705, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:17255103}; BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.81 mM for lactate {ECO:0000269|PubMed:17255103}; KM=2.03 mM for pyruvate {ECO:0000269|PubMed:17255103}; KM=23.68 mM for nicotinate {ECO:0000269|PubMed:17255103}; SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q1EHB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q1EHB4}. DEVELOPMENTAL STAGE: Expressed in brain and eye 24, 72 and 120 hours post-fertilization (hpf). At 72 hpf expressed in swim bladder and in pronephric tube. At 120 hpf expressed in brain, trabecular bar, eyes, otic capsule, stomach, gall bladder, gut and pancreas. {ECO:0000269|PubMed:17255103}. SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO:0000305}. |
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