UniProt ID: A0A8M2BD99 |
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}. |
UniProt ID: Q7SXV1 |
FUNCTION: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (PubMed:28823706). May act as a general inhibitor of innate immunity signaling (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000250|UniProtKB:Q9NUY8, ECO:0000269|PubMed:28823706}. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9NUY8}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9NUY8}. DEVELOPMENTAL STAGE: Detected as early as 1 hour post-fertilization (hpf). Primarily localized in the head at 48 hpf. {ECO:0000269|PubMed:28823706}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes reduced brain and eye size and curved tails at 48 hpf. {ECO:0000269|PubMed:28823706}. |
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