UniProt ID: Q6PGZ3 |
FUNCTION: Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000250|UniProtKB:Q8TDR0, ECO:0000269|PubMed:26487268}. SUBUNIT: Component of the IFT complex B, at least composed of ift20, ift22, ift25, ift27, ift46, ift52, traf3ip1/ift54, ift57, ift74, ift80, ift81, and ift88. Interacts with ift88 (By similarity). Interacts with il13ra1. Binds to microtubules, traf3 and disc1 (By similarity). Interacts with map4 (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000250|UniProtKB:Q8TDR0}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TDR0}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8TDR0}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q149C2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q149C2}. Note=Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip. {ECO:0000250|UniProtKB:Q8TDR0}. SIMILARITY: Belongs to the TRAF3IP1 family. {ECO:0000305}. |
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