UniProt ID: Q6TNP8 |
FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). {ECO:0000250|UniProtKB:O75436}. SUBUNIT: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). {ECO:0000250|UniProtKB:O75436}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40336}. Endosome membrane {ECO:0000250|UniProtKB:P40336}; Peripheral membrane protein {ECO:0000250|UniProtKB:P40336}. Early endosome {ECO:0000250|UniProtKB:O75436}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000250|UniProtKB:O75436}. SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}. |
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