UniProt ID: A0A8M2B948 |
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00035006}. SIMILARITY: Belongs to the calsyntenin family. {ECO:0000256|ARBA:ARBA00035015}. |
UniProt ID: F1R520 |
FUNCTION: Postsynaptic adhesion molecule involved in vesicle trafficking; required for branching of peripheral but not central axons of sensory neurons (PubMed:25009257, PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000269|PubMed:25009257, ECO:0000269|PubMed:25463516}. SUBUNIT: Homooligomer and heterooligomer; mediates both homophilic and heterophilc interactions with clstn2 and clstn3 paralogs via cadherin domains. {ECO:0000269|PubMed:25463516}. SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EPL2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EPL2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9EPL2}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}. TISSUE SPECIFICITY: By 48 hours post-fertilization (hpf), widely expressed in the brain, with strong expression in the telencephalon and the midbrain. {ECO:0000269|PubMed:25463516}. DEVELOPMENTAL STAGE: Expressed in the developing central nervous system and in sensory neurons (PubMed:25009257). Expression is detected at 4.5 hours post-fertilization (hpf) (PubMed:25463516). During development, strongly expressed in the forebrain, midbrain and hindbrain during brain development (PubMed:25463516). Compared to clstn3, expression appears broader in the telencephalon and extends more dorsally in the midbrain (PubMed:25463516). Broadly expressed in the spinal cord (PubMed:25463516). {ECO:0000269|PubMed:25009257, ECO:0000269|PubMed:25463516}. SIMILARITY: Belongs to the calsyntenin family. {ECO:0000305}. |
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