UniProt ID: Q6P0E5 |
FUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (By similarity). In response to endoplasmic reticulum stress, promotes recruitment of the E3 ufm1-protein ligase ufl1 to the endoplasmic reticulum membrane, leading to ufmylation of target proteins and subsequent reticulophagy of endoplasmic reticulum sheets (By similarity). Plays a role in cartilage development through sox9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). {ECO:0000250|UniProtKB:Q96HY6, ECO:0000269|PubMed:28263186}. SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96HY6}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96HY6}. Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress. {ECO:0000250|UniProtKB:Q96HY6}. DISRUPTION PHENOTYPE: Morpholino knockdown alters craniofacial cartilage development. {ECO:0000269|PubMed:28263186}. SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}. |
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