UniProt ID: A0A8M3AVP0 |
SIMILARITY: Belongs to the aldehyde dehydrogenase family. {ECO:0000256|RuleBase:RU003345}. |
UniProt ID: B2GT49 |
SIMILARITY: Belongs to the aldehyde dehydrogenase family. {ECO:0000256|RuleBase:RU003345}. |
UniProt ID: Q802W2 |
FUNCTION: Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. {ECO:0000250|UniProtKB:P49189}. CATALYTIC ACTIVITY: Reaction=4-(trimethylamino)butanal + H2O + NAD(+) = 4- (trimethylamino)butanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:17985, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16244, ChEBI:CHEBI:18020, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.47; Evidence={ECO:0000250|UniProtKB:P49189}; CATALYTIC ACTIVITY: Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000250|UniProtKB:P49189}; PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. {ECO:0000250|UniProtKB:P49189}. SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P49189}. SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JLJ3}. SIMILARITY: Belongs to the aldehyde dehydrogenase family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |