UniProt ID: Q803L1
CATALYTIC ACTIVITY: Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)- N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH; Xref=Rhea:RHEA:15045, Rhea:RHEA-COMP:10474, Rhea:RHEA- COMP:10475, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.8.1.4; Evidence={ECO:0000256|RuleBase:RU003692};
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRSR:PIRSR000350-3, ECO:0000256|RuleBase:RU003692}; Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR000350-3, ECO:0000256|RuleBase:RU003692};
MISCELLANEOUS: The active site is a redox-active disulfide bond. {ECO:0000256|RuleBase:RU003692}.
SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000256|RuleBase:RU003692}.
UniProt ID: Q6TNU6
CATALYTIC ACTIVITY: Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)- N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH; Xref=Rhea:RHEA:15045, Rhea:RHEA-COMP:10474, Rhea:RHEA- COMP:10475, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.8.1.4; Evidence={ECO:0000256|RuleBase:RU003692};
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRSR:PIRSR000350-3, ECO:0000256|RuleBase:RU003692}; Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR000350-3, ECO:0000256|RuleBase:RU003692};
MISCELLANEOUS: The active site is a redox-active disulfide bond. {ECO:0000256|RuleBase:RU003692}.
SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000256|RuleBase:RU003692}.
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