UniProt ID: Q6PBI4 |
FUNCTION: Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2- dependent transcription (By similarity). {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; SUBUNIT: Homodimer. Interacts with mef2 (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAQ97977.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAQ97977.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; |
UniProt ID: A0A8M2B4U1 |
CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA- COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence={ECO:0000256|ARBA:ARBA00001028}; SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. {ECO:0000256|ARBA:ARBA00007738}. |
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