UniProt ID: Q49SH1 |
FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (By similarity). Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253). Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253). {ECO:0000250|UniProtKB:Q71RS6, ECO:0000269|PubMed:16357253}. CATALYTIC ACTIVITY: Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:Q71RS6}; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:16357253}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000305|PubMed:16357253}. Note=Enriched in late-stage melanosomes. {ECO:0000250|UniProtKB:Q71RS6}. TISSUE SPECIFICITY: Highly expressed in melanin-producing cells. Colocalizes with melanin biosynthesis marker dct. {ECO:0000269|PubMed:16357253}. DEVELOPMENTAL STAGE: Expressed in the retinal pigment epithelium and in the melanopore precursors at 1 day post-fertilization. {ECO:0000269|PubMed:19414594}. DISRUPTION PHENOTYPE: Fishes show a delayed and reduced development of pigmentation. They display a diminished number, size and density of melanosomes. {ECO:0000269|PubMed:16357253}. SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. {ECO:0000305}. WEB RESOURCE: Name=Protein Spotlight; Note=Skin-deep - Issue 74 of September 2006; URL="https://web.expasy.org/spotlight/back_issues/074"; |
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