UniProt ID: Q5BKW7 |
FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. {ECO:0000250|UniProtKB:Q8BGN3}. CATALYTIC ACTIVITY: Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, ChEBI:CHEBI:295975; EC=3.1.4.38; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19546; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:44720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168, ChEBI:CHEBI:64683, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44721; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn- glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36083, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, ChEBI:CHEBI:30909, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36084; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl- sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41127, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966, ChEBI:CHEBI:75529, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41128; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41004; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- tetradecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41000; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine; Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41096; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41116; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; CATALYTIC ACTIVITY: Reaction=glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:144950, ChEBI:CHEBI:295975; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61685; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250|UniProtKB:Q8BGN3}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI- anchor {ECO:0000250}. SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. {ECO:0000305}. |
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