UniProt ID: Q7SXF1 |
FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7- dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien- 3beta-ol, two intermediates in that pathway. {ECO:0000250|UniProtKB:Q9UBM7}. CATALYTIC ACTIVITY: Reaction=cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH; Xref=Rhea:RHEA:23984, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17759, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.21; Evidence={ECO:0000250|UniProtKB:Q9UBM7}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23986; Evidence={ECO:0000250|UniProtKB:Q9UBM7}; CATALYTIC ACTIVITY: Reaction=7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+); Xref=Rhea:RHEA:46740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17737, ChEBI:CHEBI:27910, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000250|UniProtKB:O88455}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46741; Evidence={ECO:0000250|UniProtKB:O88455}; PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000250|UniProtKB:O88455}. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM7}; Multi-pass membrane protein {ECO:0000255}. SIMILARITY: Belongs to the ERG4/ERG24 family. {ECO:0000305}. |
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