UniProt ID: Q8JHZ5 |
FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. {ECO:0000256|ARBA:ARBA00024672, ECO:0000256|RuleBase:RU003304}. COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; SUBUNIT: Binds DNA as a homotetramer. {ECO:0000256|ARBA:ARBA00011393, ECO:0000256|RuleBase:RU003304}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU003304}. Nucleus {ECO:0000256|RuleBase:RU003304}. SIMILARITY: Belongs to the p53 family. {ECO:0000256|ARBA:ARBA00006167, ECO:0000256|RuleBase:RU003304}. |
UniProt ID: Q8JHZ6 |
FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. {ECO:0000256|RuleBase:RU003304}. FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. {ECO:0000256|ARBA:ARBA00024672}. COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; SUBUNIT: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. {ECO:0000256|RuleBase:RU003304}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003304}. SIMILARITY: Belongs to the p53 family. {ECO:0000256|ARBA:ARBA00006167, ECO:0000256|RuleBase:RU003304}. |
UniProt ID: Q8JFE3 |
FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. {ECO:0000256|RuleBase:RU003304}. FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. {ECO:0000256|ARBA:ARBA00024672}. COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602117-1, ECO:0000256|RuleBase:RU003304}; SUBUNIT: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. {ECO:0000256|RuleBase:RU003304}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU003304}. SIMILARITY: Belongs to the p53 family. {ECO:0000256|ARBA:ARBA00006167, ECO:0000256|RuleBase:RU003304}. |
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