UniProt ID: Q7T3T8 |
FUNCTION: mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:27913641). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of zona pellucida mRNAs, inhibiting their translation (PubMed:27913641). {ECO:0000250|UniProtKB:Q80SU3, ECO:0000269|PubMed:27913641}. SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:C3VD30}. TISSUE SPECIFICITY: Specifcally expressed in ovaries but absent in testes. {ECO:0000269|PubMed:27913641}. DEVELOPMENTAL STAGE: In oocytes, highly expressed in primary growth (stage I) and cortical alveolus (stage II) oocytes. Also detected in Stage I and II oocytes but not in stage III oocytes (at protein level). {ECO:0000269|PubMed:27913641}. DOMAIN: Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of membraneless compartments that store maternal mRNAs in oocytes. {ECO:0000250|UniProtKB:Q80SU3}. DOMAIN: The 3CxxC-type mediates binding to the 3'-UTR of mRNAs. {ECO:0000250|UniProtKB:C3VD30}. DISRUPTION PHENOTYPE: Mutants exclusively develop into adult males, due to female-to-male sex reversal (PubMed:27913641). Defects are caused by early oocyte apoptosis mediated b< the p53/tp53 pathway (PubMed:27913641). {ECO:0000269|PubMed:27913641}. SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}. |
UniProt ID: Q561Z6 |
SIMILARITY: Belongs to the ZAR1 family. {ECO:0000256|ARBA:ARBA00034699}. |
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