UniProt ID: A0A8M2BFX3 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}. |
UniProt ID: A0A8M3AZB3 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00201}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}. |
UniProt ID: Q8AXX2 |
FUNCTION: Probable transcriptional regulator involved in developmental processes (By similarity). Binds to the palindromic T site 5'- TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Is required for normal development of the pharyngeal arch arteries (By similarity). Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. {ECO:0000250|UniProtKB:O43435, ECO:0000250|UniProtKB:P70323, ECO:0000269|PubMed:12952905}. SUBUNIT: Binds DNA as a dimer. {ECO:0000250|UniProtKB:O43435}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. TISSUE SPECIFICITY: Expressed in the ear and mesendodermal components of pharyngeal arches. {ECO:0000269|PubMed:12952905}. DEVELOPMENTAL STAGE: Expression first detected at 5.0 hours post fertilization (hpf) in the dorsal blastoderm margin. Through the stage of embryonic shield formation, expression is restricted to the hypoblast, in the region of cells fated to become head and lateral plate mesoderm and pharyngeal endoderm. At 18 hpf, when the heart tube is beginning to assemble, three domains of expression can be seen: cardiac precursors, pharyngeal arch precursors and otic vesicle. These three domains remain the sites of expression to varying degrees through at least 72 hpf. By 51 hpf, expression can be seen in the cardiac outflow tract, the ventricle and the atrium, although by 72 hpf cardiac expression is strongest in the cardiac outflow tract. {ECO:0000269|PubMed:12972000}. DISRUPTION PHENOTYPE: Fishes display defects in the ear, pharyngeal arches and associated structures such as the thymus. {ECO:0000269|PubMed:12952905}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |