UniProt ID: Q801G2 |
FUNCTION: Steroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation. {ECO:0000269|PubMed:12574519, ECO:0000269|PubMed:16899559}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16899559}; Multi-pass membrane protein {ECO:0000269|PubMed:16899559}. DEVELOPMENTAL STAGE: In oocytes, expression is lowest in ovarian follicles at stages I and II but gradually increases after the onset of vitellogenic growth, peaking at vitellogenic stages (stage IIIB). {ECO:0000269|PubMed:15862564}. SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}. |
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