UniProt ID: Q6NWF6 |
FUNCTION: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000250|UniProtKB:P05787}. SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-8 associates with keratin-18 (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758}. TISSUE SPECIFICITY: Expressed in simple epithelia. {ECO:0000269|PubMed:12558605}. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. {ECO:0000255|PROSITE-ProRule:PRU01188}. |
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