UniProt ID: A2CEX1 |
FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore function in several unrelated biological processes. {ECO:0000250|UniProtKB:Q9ULC8}. CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q9ULC8}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684; Evidence={ECO:0000250|UniProtKB:Q9ULC8}; SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ULC8}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q5Y5T5}; Multi-pass membrane protein {ECO:0000255}. DEVELOPMENTAL STAGE: First detected at 2.75 hours post- fertilization/hpf (PubMed:27235108). The expression increases at least till 24 hpf (PubMed:26056731). During the segmentation period expressed in the adaxial cells and the somites in a striping pattern (PubMed:14516702). By 24 hpf, expression in the somites decreases except in the tail region. In addition expression is also detected in lens placode and lens fiber cell from 18 hpf till 48 hpf and then decreases to disappear at 60 hpf (PubMed:14516702). {ECO:0000269|PubMed:14516702, ECO:0000269|PubMed:26056731, ECO:0000269|PubMed:27235108}. DOMAIN: The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250|UniProtKB:Q8IUH5}. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. {ECO:0000305}. |
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