UniProt ID: A4QN59
FUNCTION: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250|UniProtKB:Q9CR25}.
CATALYTIC ACTIVITY: Reaction=L-histidyl-[translation elongation factor 2] + S- adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L- histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'- thioadenosine; Xref=Rhea:RHEA:36783, Rhea:RHEA-COMP:9748, Rhea:RHEA-COMP:9749, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:29979, ChEBI:CHEBI:59789, ChEBI:CHEBI:73995; EC=2.5.1.108; Evidence={ECO:0000250|UniProtKB:Q9CR25};
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
SIMILARITY: Belongs to the DPH1/DPH2 family. DPH2 subfamily. {ECO:0000305}.
UniProt ID: E9QFV0
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000256|SAAS:SAAS00738906}.
SIMILARITY: Belongs to the DPH1/DPH2 family. {ECO:0000256|SAAS:SAAS00738904}.
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