UniProt ID: P59889 |
FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. {ECO:0000269|PubMed:15683366}. CATALYTIC ACTIVITY: Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:15683366}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29352; Evidence={ECO:0000269|PubMed:15683366}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NY26}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NY26}; Multi-pass membrane protein {ECO:0000255}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. {ECO:0000250|UniProtKB:Q9NY26}. TISSUE SPECIFICITY: Ubiquitous. Highest levels in ovary, high levels in heart, eye, kidney and brain, moderate levels in intestine and low levels in gill and skin. {ECO:0000269|PubMed:15683366}. SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. {ECO:0000305}. |
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