UniProt ID: X1WGX5 |
FUNCTION: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (By similarity). Binds to double-stranded RNA or DNA without sequence specificity (By similarity). Involved in development of the eye and of primordial germ cells (PubMed:19319195). {ECO:0000250|UniProtKB:Q15397, ECO:0000269|PubMed:19319195}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q15397}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15397}. Chromosome {ECO:0000250|UniProtKB:Q15397}. TISSUE SPECIFICITY: In adult, expressed at high levels in eye and ovary and at lower levels in brain, testis and head kidney. In the adult ovary, prominently expressed in early immature follicles. {ECO:0000269|PubMed:19319195}. DEVELOPMENTAL STAGE: Expressed throughout embryogenesis. In the adult ovary, strong expression detected in primitive stage I ovarian follicles with levels declining sharply and becoming negligible in subsequent stages of oocyte development. {ECO:0000269|PubMed:19319195}. DOMAIN: A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein. {ECO:0000250|UniProtKB:Q15397}. DISRUPTION PHENOTYPE: Morpholino knockdown in embryos results in small eyes, small head and brain edema at 1 and 2 days post-fertilization (dpf). At 3 and 5 dpf, mutants exhibit features of an undifferentiated retina with loss of detailed architecture and a significant reduction in eye size. Structures such as the rod and cone layers are not concentrically organized and retinal ganglion cells and plexiform layers are not readily discernible. Mutants also show abnormal primordial germ cell migration. {ECO:0000269|PubMed:19319195}. |
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