UniProt ID: A0A8M1NZL3 |
FUNCTION: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes. {ECO:0000256|RuleBase:RU369073}. SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000256|RuleBase:RU369073}. SIMILARITY: Belongs to the THAP1 family. {ECO:0000256|RuleBase:RU369073}. |
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