UniProt ID: Q5RID7
FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). {ECO:0000250|UniProtKB:Q15036, ECO:0000250|UniProtKB:Q8BVL3}.
SUBUNIT: Monomer (By similarity). Interacts with CCDC22, CCDC93, DSCR3 and VPS35L; the interaction with DSCR3 is direct and associates SNX17 with the retriever and CCC complexes (By similarity). {ECO:0000250|UniProtKB:Q15036}.
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15036}. Early endosome {ECO:0000250|UniProtKB:Q15036}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q15036}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15036}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15036}.
DOMAIN: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes. {ECO:0000250|UniProtKB:Q15036}.
DOMAIN: The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS. {ECO:0000250|UniProtKB:Q15036}.
SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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