UniProt ID: Q2YDQ5 |
FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity). {ECO:0000250}. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. DOMAIN: The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded (By similarity). {ECO:0000250}. PTM: Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity). {ECO:0000250}. SEQUENCE CAUTION: Sequence=AAI10115.1; Type=Frameshift; Evidence={ECO:0000305}; |
UniProt ID: F1QLP2 |
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |