UniProt ID: Q7ZV43 |
FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity). {ECO:0000250|UniProtKB:Q9H0E2}. SUBUNIT: Oligomerizes (By similarity). Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). Found in a complex with TOM1; interacts (via N-terminus) with TOM1 (via GAT domain); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q9H0E2}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0E2}. Endosome {ECO:0000250|UniProtKB:Q9H0E2}. Early endosome {ECO:0000250|UniProtKB:Q9H0E2}. Note=Localized to endo/exosomal vesicles. {ECO:0000250|UniProtKB:Q9H0E2}. DOMAIN: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins. {ECO:0000250|UniProtKB:Q9H0E2}. DOMAIN: The N-terminal TOM1-binding domain (residues 1-53) is a disordered domain that partially folds when bound to the GAT domain of TOM1. {ECO:0000250|UniProtKB:Q9H0E2}. SIMILARITY: Belongs to the tollip family. {ECO:0000305}. |
UniProt ID: A0A0R4IVK4 |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. SIMILARITY: Belongs to the tollip family. {ECO:0000256|ARBA:ARBA00009278}. |
UniProt ID: A0A0R4IZ33 |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. SIMILARITY: Belongs to the tollip family. {ECO:0000256|ARBA:ARBA00009278}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |