UniProt ID: Q7ZV43
FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). {ECO:0000250}.
SUBUNIT: Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). {ECO:0000250}.
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
DOMAIN: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins. {ECO:0000250}.
SIMILARITY: Belongs to the tollip family. {ECO:0000305}.
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