UniProt ID: A0MS83 |
FUNCTION: Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development. {ECO:0000269|PubMed:16914492}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. DEVELOPMENTAL STAGE: Detected in posterior lateral mesoderm, head mesenchyme and the intermediate cell mass in embryos 24 hours after fertilization. {ECO:0000269|PubMed:16914492}. MISCELLANEOUS: Knock-down of the znf148 mRNA disrupts both primitive and definitive hematopoiesis, but does not affect primary blood vessel formation. Most embryos die before four days after fertilization. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
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