UniProt ID: Q7T2E3 |
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). {ECO:0000250}. CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; ACTIVITY REGULATION: Exhibits substrate-dependent heparin activation. {ECO:0000250}. SUBUNIT: Monomer (By similarity). Interacts with per1 and per2. Component of the circadian core oscillator (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. DEVELOPMENTAL STAGE: Ubiquitously expressed in embryos until eight hours after fertilization. Detected throughout the embryo, but particularly in the cephalic region, at 10 to 24 hours after fertilization. Detected in retina, tegmentum and myencephalon at 38 and 48 hours after fertilization. {ECO:0000269|PubMed:18064361}. PTM: Autophosphorylated on serine and threonine residues. {ECO:0000250}. SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}. |
UniProt ID: A0A286YAS3 |
SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000256|RuleBase:RU000304}. |
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