UniProt ID: Q6DRM0 |
FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (By similarity). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required to ensure correct topology and ER insertion of CAMLG (By similarity). {ECO:0000250|UniProtKB:O00258}. SUBUNIT: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40. Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. {ECO:0000250|UniProtKB:O00258}. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00258}; Multi-pass membrane protein {ECO:0000255}. SIMILARITY: Belongs to the WRB/GET1 family. {ECO:0000305}. |
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