UniProt ID: Q803B3 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707, ECO:0000256|RuleBase:RU366025}; SUBUNIT: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. {ECO:0000256|ARBA:ARBA00025823}. SIMILARITY: Belongs to the peptidase C19 family. USP14/UBP6 subfamily. {ECO:0000256|ARBA:ARBA00008739}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |