UniProt ID: Q6NV32 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. TISSUE SPECIFICITY: At the 20-somite stage (18 hpf), expressed on the dorsal side of the embryo in the developing central and peripheral nervous system (CNS and PNS), in the tail bud and the pronephric ducts. In the PNS, expressed in the otic vesicle, trigeminal ganglion and the anterior lateral line placode. Localized throughout the hindbrain, with highest expression in rhombomeres 3 and 4. In the head, expressed in the olfactory placode and in the diencephalic region. At the end of the segmentation period (20 hpf), expression begins in the newly forming endodermal pouches, and weakly in the pharyngeal arch precursor cells. During the early pharyngula period, expressed in the pectoral fin bud, the developing retina, and still present in the central nervous system and endodermal pouches. In the tail, expressed in the spinal cord and posterior lateral line precursors. Weakly expressed in the pronephric ducts, only in the corpuscles of Stanius. At 48 hpf, still expressed in the retina and brain, where expression is almost uniform. At this stage, expression is decreased in the spinal cord and is absent from the lateral line cells and pronephric ducts, but appears in the intestine and continues in the pharyngeal arches. In 72 hpf embryos, expression in the brain remains uniform but is restricted to amacrine cells in the retina. In the pharyngeal arches, expression continues to be limited to the ectodermal and endodermal covering cells. {ECO:0000269|PubMed:18351673}. DEVELOPMENTAL STAGE: Expression begins at 16 hpf and gradually increases up to 72 hpf. {ECO:0000269|PubMed:18351673}. SIMILARITY: Belongs to the pro/parathymosin family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |