UniProt ID: Q7ZV37 |
FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000256|ARBA:ARBA00024698}. CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA- COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; Evidence={ECO:0000256|ARBA:ARBA00000906}; SUBUNIT: Binds PPP2CA and PPP2CB. {ECO:0000256|ARBA:ARBA00011604}. SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000256|ARBA:ARBA00008645, ECO:0000256|PIRNR:PIRNR022950}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |