UniProt ID: Q6P2T8 |
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. {ECO:0000256|RuleBase:RU364024}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364024}. SIMILARITY: Belongs to the TFB2 family. {ECO:0000256|ARBA:ARBA00007132, ECO:0000256|RuleBase:RU364024}. |
UniProt ID: F1R096 |
FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000256|RuleBase:RU369054}. SUBUNIT: Interacts with GDP-bound and nucleotide-free forms of RAB11A. {ECO:0000256|RuleBase:RU369054}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369054}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000256|RuleBase:RU369054}. DOMAIN: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. {ECO:0000256|RuleBase:RU369054}. SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000256|ARBA:ARBA00007796, ECO:0000256|RuleBase:RU369054}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |