UniProt ID: B2GQ15 |
CATALYTIC ACTIVITY: Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283}; PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000256|ARBA:ARBA00005005}. SIMILARITY: Belongs to the carnitine/choline acetyltransferase family. {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}. |
UniProt ID: Q5U3U3 |
FUNCTION: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. {ECO:0000250|UniProtKB:P23786}. CATALYTIC ACTIVITY: Reaction=(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)- carnitine; Xref=Rhea:RHEA:12661, ChEBI:CHEBI:16347, ChEBI:CHEBI:17490, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=2.3.1.21; Evidence={ECO:0000250|UniProtKB:P23786}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:12663; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine; Xref=Rhea:RHEA:17177, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine; Xref=Rhea:RHEA:44828, ChEBI:CHEBI:16347, ChEBI:CHEBI:28717, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R- carnitine; Xref=Rhea:RHEA:40279, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:77086; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)- carnitine; Xref=Rhea:RHEA:44832, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:84634; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)- carnitine; Xref=Rhea:RHEA:44840, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:84644; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)- carnitine; Xref=Rhea:RHEA:44844, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:84645; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)- tetradecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44848, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:65060, ChEBI:CHEBI:84647; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)- tetradecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44852, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:84649, ChEBI:CHEBI:84650; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)- octadecenoyl-(R)-carnitine; Xref=Rhea:RHEA:44856, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:84651; Evidence={ECO:0000250|UniProtKB:P23786}; CATALYTIC ACTIVITY: Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence={ECO:0000250|UniProtKB:P23786}; PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P23786}. SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}. SIMILARITY: Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH85392.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
This information was provided by UniProt through a collaboration with ZFIN. (1) |