UniProt ID: E7FH24 |
FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription. {ECO:0000256|HAMAP-Rule:MF_03071}. CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665, ECO:0000256|HAMAP- Rule:MF_03071}; SUBUNIT: Component of some MLL1/MLL complex. {ECO:0000256|HAMAP- Rule:MF_03071}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03071}. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. {ECO:0000256|HAMAP-Rule:MF_03071}. |
UniProt ID: A0A8M9QGD7 |
FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription. {ECO:0000256|HAMAP-Rule:MF_03071}. CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665, ECO:0000256|HAMAP- Rule:MF_03071}; SUBUNIT: Component of some MLL1/MLL complex. {ECO:0000256|HAMAP- Rule:MF_03071}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03071}. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. {ECO:0000256|HAMAP-Rule:MF_03071}. |
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