UniProt ID: A0A8M3B6H6 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364107}. SIMILARITY: Belongs to the SCC2/Nipped-B family. {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}. |
UniProt ID: F1QBY1 |
FUNCTION: May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading (PubMed:22039349). Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22039349}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6KCD5}. DEVELOPMENTAL STAGE: Detected in the early blastula, 2.5 hours post fertilization (hpf), before the onset of zygotic gene expression, and expression progressively increases, reaching a peak at late gastrula stages (9 hpf), before decreasing by 26 hpf. Maternal transcripts are detected throughout the blastoderm. Ubiquitous expression continues until early somitogenesis (12 hpf), after which transcript levels gradually decrease in the trunk (15-18 hpf), with strong expression becoming restricted to the head by 25 hpf. {ECO:0000269|PubMed:22039349}. DOMAIN: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain (By similarity). {ECO:0000250|UniProtKB:Q6KC79}. SIMILARITY: Belongs to the SCC2/Nipped-B family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAI29433.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; |
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