UniProt ID: Q7ZWA3 |
FUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain. {ECO:0000250, ECO:0000269|PubMed:15895365}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Expressed widely in the embryo up to 24 hr post-fertilization (hpf). Expressed predominantly in the brain, branchial arches, and liver primordium between 24 to 72 hpf. Expressed in the midbrain at 7 days post-fertilization (dpf). {ECO:0000269|PubMed:15895365}. |
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