UniProt ID: A0A8M2BKN4 |
FUNCTION: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000256|HAMAP-Rule:MF_03212}. CATALYTIC ACTIVITY: Reaction=NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]; Xref=Rhea:RHEA:24040, Rhea:RHEA- COMP:14627, Rhea:RHEA-COMP:14628, ChEBI:CHEBI:15378, ChEBI:CHEBI:55376, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60344; EC=1.6.2.4; Evidence={ECO:0000256|HAMAP- Rule:MF_03212}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|HAMAP-Rule:MF_03212}; Note=Binds 1 FAD per monomer. {ECO:0000256|HAMAP-Rule:MF_03212}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|HAMAP-Rule:MF_03212}; Note=Binds 1 FMN per monomer. {ECO:0000256|HAMAP-Rule:MF_03212}; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000256|HAMAP- Rule:MF_03212}. SIMILARITY: Belongs to the NADPH--cytochrome P450 reductase family. {ECO:0000256|HAMAP-Rule:MF_03212}. SIMILARITY: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000256|HAMAP- Rule:MF_03212}. SIMILARITY: In the N-terminal section; belongs to the flavodoxin family. {ECO:0000256|HAMAP-Rule:MF_03212}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03212}. |
UniProt ID: F8W4Z6 |
FUNCTION: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000256|HAMAP-Rule:MF_03212}. CATALYTIC ACTIVITY: Reaction=NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]; Xref=Rhea:RHEA:24040, Rhea:RHEA- COMP:14627, Rhea:RHEA-COMP:14628, ChEBI:CHEBI:15378, ChEBI:CHEBI:55376, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60344; EC=1.6.2.4; Evidence={ECO:0000256|HAMAP- Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|HAMAP-Rule:MF_03212}; Note=Binds 1 FAD per monomer. {ECO:0000256|HAMAP-Rule:MF_03212}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|HAMAP-Rule:MF_03212}; Note=Binds 1 FMN per monomer. {ECO:0000256|HAMAP-Rule:MF_03212}; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000256|HAMAP- Rule:MF_03212}. SIMILARITY: Belongs to the NADPH--cytochrome P450 reductase family. {ECO:0000256|HAMAP-Rule:MF_03212}. SIMILARITY: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000256|HAMAP- Rule:MF_03212, ECO:0000256|PIRNR:PIRNR000208}. SIMILARITY: In the N-terminal section; belongs to the flavodoxin family. {ECO:0000256|HAMAP-Rule:MF_03212}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03212}. |
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